Brooklyn teenager Miles Morales is trying to navigate the pressures of school, family, and finding his identity when an unexpected event changes everything. After being bitten by a radioactive spider, Miles gains extraordinary powers similar to the legendary Spider-Man. As he grapples with the responsibilities that come with these new abilities, he stumbles upon a super collider built by the villainous Wilson "Kingpin" Fisk. The device inadvertently opens a portal, pulling other versions of Spider-Man from across the multiverse into Miles' world. Now, he must join forces with these unlikely allies to stop Fisk’s dangerous plans and protect his reality.