In 1926, Newt Scamander arrives at the Magical Congress of the United States of America with a special briefcase that magically houses a variety of dangerous creatures and their habitats. However, when some of these creatures unexpectedly escape, it sparks chaos, drawing the attention of American wizarding authorities. As Newt races to recapture the creatures, his actions put even more strain on the already fragile relationship between the magical and non-magical communities, threatening to expose secrets that could disrupt both worlds.