After marine Ray Garrison and his wife are brutally murdered, a team of scientists brings him back to life using cutting-edge nanotechnology, transforming him into a superhuman killing machine known as "Bloodshot." As he trains alongside other enhanced soldiers, Ray struggles with a lost past and the emptiness of his new existence. However, when fragmented memories resurface, and he recalls the man responsible for his and his wife’s deaths, Ray breaks free from the facility in a quest for vengeance. Along the way, he uncovers a far-reaching conspiracy that challenges everything he thought he knew about his past, his enemies, and the true nature of his resurrection.